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JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.
Li, Juan; Kent, David G; Godfrey, Anna L; Manning, Harriet; Nangalia, Jyoti; Aziz, Athar; Chen, Edwin; Saeb-Parsy, Kourosh; Fink, Juergen; Sneade, Rachel; Hamilton, Tina L; Pask, Dean C; Silber, Yvonne; Zhao, Xiaodong; Ghevaert, Cedric; Liu, Pentao; Green, Anthony R.
Afiliação
  • Li J; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Kent DG; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Godfrey AL; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingd
  • Manning H; Department of Haematology, University of Cambridge, United Kingdom; National Health Service Blood and Transplant, Cambridge, United Kingdom;
  • Nangalia J; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingd
  • Aziz A; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Chen E; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, United Kingdom; and.
  • Fink J; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Sneade R; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Hamilton TL; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Pask DC; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Silber Y; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Zhao X; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom;
  • Ghevaert C; Department of Haematology, University of Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom; National Health Service Blood and Transplant, Cambridge, United Kingdom;
  • Liu P; Welcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
  • Green AR; Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, United Kingdom; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingd
Blood ; 123(20): 3139-51, 2014 May 15.
Article em En | MEDLINE | ID: mdl-24692758
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Policitemia Vera / Janus Quinase 2 / Trombocitemia Essencial / Mutação Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Policitemia Vera / Janus Quinase 2 / Trombocitemia Essencial / Mutação Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article