Novel submicronized rebamipide liquid with moderate viscosity: significant effects on oral mucositis in animal models.
Biol Pharm Bull
; 37(4): 671-8, 2014.
Article
em En
| MEDLINE
| ID: mdl-24694614
ABSTRACT
This study aimed at developing a novel rebamipide liquid for an effective treatment of oral mucositis. The healing effects of a variety of liquids comprising submicronized rebamipide crystals were investigated using a rat cauterization-induced oral ulcer model. Whereas 2% rebamipide liquid comprising micro-crystals did not exhibit significant curative effect, 2% rebamipide liquids comprising submicronized crystals with moderate viscosities exhibited healing effects following intra-oral administration. The 2% and 4% optimized rebamipide liquids showed significant healing effects in the rat oral ulcer model (p<0.01). In addition, in the rat radiation-induced glossitis model, whereby the injury was caused to the tongue by exposing only around the rat's snout to a 15 Gy of X-irradiation, the 2% optimized rebamipide liquid significantly reduced the percent area of ulcerated injury (p<0.05). In conclusion, the submicronized rebamipide liquid with moderate viscosity following intra-oral administration showed better both healing effect in the rat oral ulcer model and preventive effect in the rat irradiation-induced glossitis model.
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Base de dados:
MEDLINE
Assunto principal:
Estomatite
/
Viscosidade
/
Quinolonas
/
Alanina
/
Glossite
/
Antiulcerosos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article