Early radiation-induced changes evaluated by intravoxel incoherent motion in the major salivary glands.
J Magn Reson Imaging
; 41(4): 974-82, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-24700435
ABSTRACT
PURPOSE:
To investigate the potential of intravoxel incoherent motion (IVIM) MRI for early evaluation of irradiated major salivary glands. MATERIALS ANDMETHODS:
Thirty-four patients with head-neck cancer were included in a prospective study. All patients underwent three serial IVIM-MRI before, half-way through, and at the end of radiotherapy (RT). Apparent diffusion coefficient (ADC), ADClow derived in the low b-value range, perfusion fraction f, and pure diffusion coefficient D were estimated. Pretreatment values and early changes of diffusion parameters were correlated with parotid mean dose (Dmean ) and volume reduction after RT.RESULTS:
Changes in diffusion parameters over time were all significant (P < 0.001 for ADC, ADClow , and D, P = 0.003 for f). Variations of ADC, ADClow , and f were not correlated with Dmean (P = 0.089, P = 0.252 and P = 0.884, respectively), whereas a significant relationship was found between changes in D and Dmean (r = 0.197 with CI95% = 0.004-0.375, P = 0.046). Pretreatment f and Dmean were the best independent predictors for the percentage shrinkage (P = 0.0003 and 0.0597 respectively; R(2) = 0.391).CONCLUSION:
Early changes of irradiated major salivary glands can be noninvasively evaluated by IVIM-MRI. Perfusion-related coefficients in conjunction with dosimetric information increase our capability to predict the change in parotid volume and hence, if further validated, guide treatment strategy in RT.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças das Glândulas Salivares
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Imageamento por Ressonância Magnética
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Interpretação de Imagem Assistida por Computador
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Radioterapia Conformacional
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Neoplasias de Cabeça e Pescoço
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article