Modular construction of dynamic nucleodendrimers.
Angew Chem Int Ed Engl
; 53(19): 4862-6, 2014 May 05.
Article
em En
| MEDLINE
| ID: mdl-24700537
ABSTRACT
Isoguanosine-containing dendritic small molecules self-assemble into decameric nucleodendrimers as observed by 1Dâ
NMR spectroscopy, 2Dâ
DOSY, and mass spectrometry. In particular, apolar building blocks readily form pentameric structures in acetonitrile while the presence of alkali metals promotes the formation of stable decameric assemblies with a preference for cesium ions. Remarkably, co-incubation of guanosine and isoguanosine-containing nucleodendrons results in the formation of decameric structures in absence of added salts. Further analysis of the mixture indicated that guanosine derivatives facilitate the formation, but are not involved in decameric structures; a process reminiscent of molecular crowding. This molecular system provides a powerful canvas for the rapid and modular assembly of polyfunctional dendritic macromolecules.
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MEDLINE
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En
Ano de publicação:
2014
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Article