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New advances in CMV and immunosenescence.
Sansoni, Paolo; Vescovini, Rosanna; Fagnoni, Francesco F; Akbar, Arne; Arens, Ramon; Chiu, Yen-Ling; Cicin-Sain, Luka; Dechanet-Merville, Julie; Derhovanessian, Evelyna; Ferrando-Martinez, Sara; Franceschi, Claudio; Frasca, Daniela; Fulöp, Tamas; Furman, David; Gkrania-Klotsas, Effrossyni; Goodrum, Felicia; Grubeck-Loebenstein, Beatrix; Hurme, Mikko; Kern, Florian; Lilleri, Daniele; López-Botet, Miguel; Maier, Andrea B; Marandu, Thomas; Marchant, Arnaud; Matheï, Catharina; Moss, Paul; Muntasell, Aura; Remmerswaal, Ester B M; Riddell, Natalie E; Rothe, Kathrin; Sauce, Delphine; Shin, Eui-Cheol; Simanek, Amanda M; Smithey, Megan J; Söderberg-Nauclér, Cecilia; Solana, Rafael; Thomas, Paul G; van Lier, Rene; Pawelec, Graham; Nikolich-Zugich, Janko.
Afiliação
  • Sansoni P; Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy. Electronic address: paolo.sansoni@unipr.it.
  • Vescovini R; Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
  • Fagnoni FF; Immunohematology and Transfusion Center, Hospital of Parma, Parma, Italy.
  • Akbar A; Division of Infection and Immunity, University College London, London, United Kingdom.
  • Arens R; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
  • Chiu YL; Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Cicin-Sain L; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Dechanet-Merville J; Composantes Innées de la Response Immunitaire et Différenciation, University of Bordeaux, Bordeaux, France.
  • Derhovanessian E; Department of Internal Medicine II, Center for Medical Research University of Tübingen, Tübingen, Germany.
  • Ferrando-Martinez S; Laboratorio de InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
  • Franceschi C; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
  • Frasca D; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Fulöp T; Division of Geriatrics and Research Center on Aging, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
  • Furman D; Composantes Innées de la Response Immunitaire et Différenciation, University of Bordeaux, Bordeaux, France; Department of Microbiology & Immunology, School of Medicine, Stanford University, CA, USA.
  • Gkrania-Klotsas E; Medical Research Council Epidemiology Unit, Cambridge, United Kingdom.
  • Goodrum F; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA.
  • Grubeck-Loebenstein B; Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
  • Hurme M; Department of Microbiology and Immunology, University of Tampere, Tampere, Finland.
  • Kern F; Division of Medicine, Pathogen Host Interaction (PHI), Brighton and Sussex Medical School, Brighton, United Kingdom.
  • Lilleri D; Laboratori Sperimentali di Ricerca, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • López-Botet M; Immunology Unity, University Pompeu Fabra and Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Maier AB; Section of Gerontology and Geriatrics, Department of Internal Medicine, VU University Medical Center, Amsterdam, Netherlands.
  • Marandu T; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Marchant A; Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
  • Matheï C; KU Leuven, Department of Public Health and Primary Care, Leuven, Belgium.
  • Moss P; School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom.
  • Muntasell A; Immunology Unity, University Pompeu Fabra and Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Remmerswaal EB; Department of Experimental Immunology and Renal Transplant Unit, Department of Internal Medicine, Amsterdam, Netherlands.
  • Riddell NE; Division of Infection and Immunity, University College London, London, United Kingdom.
  • Rothe K; Section of Rheumatology, University of Leipzig, Leipzig, Germany.
  • Sauce D; INSERM, Infections and Immunity, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris, France.
  • Shin EC; Laboratory of Immunology and Infectious Diseases (LIID), Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
  • Simanek AM; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Smithey MJ; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA.
  • Söderberg-Nauclér C; Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  • Solana R; Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
  • Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • van Lier R; Division of Research, Sanquin Blood Supply Foundation, Amsterdam, Netherlands.
  • Pawelec G; Department of Internal Medicine II, Center for Medical Research University of Tübingen, Tübingen, Germany.
  • Nikolich-Zugich J; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA. Electronic address: jnikolich@medadmin.arizona.edu.
Exp Gerontol ; 55: 54-62, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24703889
Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Infecções por Citomegalovirus Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Infecções por Citomegalovirus Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article