Elevated expression of Bmi1 in hepatocellular carcinoma with bile duct tumor thrombi.
Hepatogastroenterology
; 60(128): 2042-7, 2013.
Article
em En
| MEDLINE
| ID: mdl-24719948
ABSTRACT
BACKGROUND/AIMS:
Hepatocellular carcinoma (HCC) with bile duct tumor thrombi (BDTT) is a rare event. The Bmi1 gene has been reported to play important roles in cancer initiation and progression. In this study, the expression of Bmi1 in HCC with BDTT was investigated.METHODOLOGY:
The expression of Bmi1 was examined immunohistochemically in HCC patients with BDTT (B+ group), HCC patients with vascular invasion (V+ group) and combined hepatocellular carcinoma and cholangiocarcinoma (C+ group), respectively. Besides, the Bmi1 mRNA level was investigated by real time PCR in the fresh samples obtained from 13 cases in B+ group, 10 cases in V+ group, and 6 cases in C+ group, respectively.RESULTS:
Immunohistochemical staining for Bmi1 showed Bmi1 was highly expressed in the B+ group in comparison with the C+ group and the V+ group, respectively. The Bmi1 mRNA level by real time PCR also showed that it was significantly up-regulated in B+ group compared with those of C+ group and V+ group, respectively. However, there was no statistically significant difference in Bmi1 levels between the subjects with vascular invasion and the subjects without vascular invasion.CONCLUSIONS:
Bmi1 might play important roles in the development of BDTT in HCC.
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Base de dados:
MEDLINE
Assunto principal:
Ductos Biliares Intra-Hepáticos
/
Biomarcadores Tumorais
/
Carcinoma Hepatocelular
/
Complexo Repressor Polycomb 1
/
Neoplasias Hepáticas
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article