T lymphocytes and NK cells in X-linked agammaglobulinemia.
Przegl Lek
; 70(12): 1048-50, 2013.
Article
em En
| MEDLINE
| ID: mdl-24720125
ABSTRACT
Seven boys with diagnosis of X-linked agammaglobulinemia on regular substitution of immunoglobulins were included into study. The patients showed episodes of infections but the clinical course was mild with good response to antibiotics. All patients developed, with time, the chronic sinusitis with proliferation of mucous membrane, two patients showed bronchiectases. The number of T lymphocytes, ratio of CD4CD8 subpopulations, response to stimulation and NK number were assayed with flow cytometry and cell culture. Results showed CD4CD8 ratio within normal value in majority of patients, reverse ratio in 2 boys, increased number of activated T cells (CD3/HLA-DR) in one of them. The number of NK cells was different from lack of these cells to high number. Response of T cells to stimulation (mitogens and CD3) were normal in majority of assays. There were no associations between clinical course and observed changes in T or NK cell populations. Further studies on number and function of NK cells are needed.
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Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Linfócitos T
/
Agamaglobulinemia
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Doenças Genéticas Ligadas ao Cromossomo X
Limite:
Child
/
Child, preschool
/
Humans
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Infant
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Male
/
Newborn
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article