Syk inhibitors with high potency in presence of blood.
Bioorg Med Chem Lett
; 24(10): 2278-82, 2014 May 15.
Article
em En
| MEDLINE
| ID: mdl-24726806
ABSTRACT
We describe two series of Syk inhibitors which potently abrogate Syk kinase function in enzymatic assays, cellular assays and in primary cells in the presence of blood. Introduction of a 7-aminoindole substituent led to derivatives with good kinase selectivity and little or no hERG channel inhibition (3b, 10c).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Inibidores de Proteínas Quinases
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article