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High resolution imaging beyond the acoustic diffraction limit in deep tissue via ultrasound-switchable NIR fluorescence.
Pei, Yanbo; Wei, Ming-Yuan; Cheng, Bingbing; Liu, Yuan; Xie, Zhiwei; Nguyen, Kytai; Yuan, Baohong.
Afiliação
  • Pei Y; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA [3].
  • Wei MY; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA [3].
  • Cheng B; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
  • Liu Y; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
  • Xie Z; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA [3].
  • Nguyen K; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
  • Yuan B; 1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
Sci Rep ; 4: 4690, 2014 Apr 15.
Article em En | MEDLINE | ID: mdl-24732947
ABSTRACT
Fluorescence imaging in deep tissue with high spatial resolution is highly desirable because it can provide details about tissue's structural, functional, and molecular information. Unfortunately, current fluorescence imaging techniques are limited either in penetration depth (microscopy) or spatial resolution (diffuse light based imaging) as a result of strong light scattering in deep tissue. To overcome this limitation, we developed an ultrasound-switchable fluorescence (USF) imaging technique whereby ultrasound was used to switch on/off the emission of near infrared (NIR) fluorophores. We synthesized and characterized unique NIR USF contrast agents. The excellent switching properties of these agents, combined with the sensitive USF imaging system developed in this study, enabled us to image fluorescent targets in deep tissue with spatial resolution beyond the acoustic diffraction limit.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imagem Óptica / Corantes Fluorescentes / Músculos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imagem Óptica / Corantes Fluorescentes / Músculos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article