SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.
Bioorg Med Chem Lett
; 24(10): 2374-8, 2014 May 15.
Article
em En
| MEDLINE
| ID: mdl-24736115
ABSTRACT
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
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Base de dados:
MEDLINE
Assunto principal:
Dextranos
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Proteínas Mitocondriais
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Peptídeos e Proteínas de Sinalização Intracelular
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Nanopartículas de Magnetita
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article