Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study.
Eur Heart J
; 35(42): 2972-9, 2014 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-24742886
ABSTRACT
OBJECTIVE:
To examine the relation of endothelial microparticles (EMPs) with cardiometabolic risk in the community.BACKGROUND:
Circulating EMPs are small membrane vesicles released after endothelial cell injury. Endothelial microparticles are reportedly increased among individuals with a high burden of cardiovascular risk factors. However, prior investigations have been limited to small, highly selected samples.METHODS:
We studied 844 individuals without a history of cardiovascular disease in the Framingham Offspring cohort (mean age 66 ± 9 years, 57% women). We used standardized flow cytometry methods to identify and quantify circulating CD144+ and CD31+/CD41- EMPs. We then used multivariable regression analyses to investigate the relations of EMP phenotypes with cardiovascular and metabolic risk factors.RESULTS:
In multivariable analyses, the following cardiovascular risk factors were associated with one or more of the circulating EMP populations hypertension (P = 0.025 for CD144+,), elevated triglycerides (P = 0.002 for CD144+, P < 0.0001 for CD31+/CD41-), and metabolic syndrome (P < 0.0001 for CD144+,). Overall, each tertile increase in the Framingham risk score corresponded to a 9% increase in log-CD31+/CD41- EMPs (P = 0.022). Furthermore, the presence of hypertriglyceridaemic waist status was associated with 38% higher levels of CD144+ EMPs (P < 0.0001) and 46% higher levels of CD31+/CD41- EMPs (P < 0.0001).CONCLUSION:
In a large community-based sample, circulating EMP levels were associated with the presence of cardiometabolic risk factors, particularly dyslipidaemia. These data underscore the potential influence of high-risk metabolic profiles on endothelial integrity.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Doenças Cardiovasculares
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Síndrome Metabólica
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Micropartículas Derivadas de Células
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article