Bacterial translocation in alymphoplasia (aly/aly) mice.
Folia Biol (Krakow)
; 62(1): 9-12, 2014.
Article
em En
| MEDLINE
| ID: mdl-24745143
ABSTRACT
Bacterial translocation (BTL) is defined as the passage of viable bacteria from the gastrointestinal tract to the organs. This study was to elucidate the roles of Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) in BTL. Alymphoplastic mutant mice and phenotypically normal heterozygous micewere dominantly colonized with streptomycin-resistant Escherichia coli and BTL was examined. In PP- and MLN-competent mice, BTL to MLNs was detected in 100% of mice, but BTL to organs was rare (25%). On the other hand, in PP- and MLN-deficientmice, BTL to organs was detected in 91% of mice. The results clearly indicate that PPs are not the only site for bacterial entry.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Serina-Treonina Quinases
/
Translocação Bacteriana
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article