Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary.
Molecules
; 19(4): 4956-66, 2014 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-24747651
ABSTRACT
Many recent studies have suggested that activation of the aryl hydrocarbon receptor (AhR) reduces immune responses, thus suppressing allergies and autoimmune diseases. In our continuing study on natural AhR agonists in foods, we examined the influence of 37 health food materials on the AhR using a reporter gene assay, and found that aqueous ethanol extracts of cassia seed and rosemary had particularly high AhR activity. To characterize the AhR-activating substances in these samples, the chemical constituents of the respective extracts were identified. From an active ethyl acetate fraction of the cassia seed extract, eight aromatic compounds were isolated. Among these compounds, aurantio-obtusin, an anthraquinone, elicited marked AhR activation. Chromatographic separation of an active ethyl acetate fraction of the rosemary extract gave nine compounds. Among these compounds, cirsimaritin induced AhR activity at 10-10² µM, and nepitrin and homoplantagenin, which are flavone glucosides, showed marked AhR activation at 10-10³ µM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sementes
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Cassia
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Receptores de Hidrocarboneto Arílico
/
Folhas de Planta
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Ledum
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Fatores Imunológicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article