Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice.

Rickenbacher, Andreas; Jang, Jae Hwi; Limani, Perparim; Ungethüm, Udo; Lehmann, Kuno; Oberkofler, Christian E; Weber, Achim; Graf, Rolf; Humar, Bostjan; Clavien, Pierre-Alain

Rickenbacher, Andreas; Jang, Jae Hwi; Limani, Perparim; Ungethüm, Udo; Lehmann, Kuno; Oberkofler, Christian E; Weber, Achim; Graf, Rolf; Humar, Bostjan; Clavien, Pierre-Alain.

Afiliação

Rickenbacher A; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Jang JH; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Limani P; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Ungethüm U; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Lehmann K; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Oberkofler CE; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Weber A; Institute of Pathology, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Graf R; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Humar B; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland.
Clavien PA; Swiss Hepato-Pancreatico-Biliary Center, Department of Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland. Electronic address: clavien@access.uzh.ch.

J Hepatol ; 61(2): 301-8, 2014 Aug.

Article em En | MEDLINE | ID: mdl-24751831

Assuntos

Jejum; Proteína HMGB1/sangue; Fígado/irrigação sanguínea; Traumatismo por Reperfusão/prevenção & controle; Sirtuína 1/fisiologia; Animais; Regulação para Baixo; Proteína HMGB1/fisiologia; Inflamação/prevenção & controle; Masculino; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

Anti-inflammatory; Autophagy; Fasting; HMGB1; Innate immunity; Kupffer cell; Liver ischemia; Sirtuin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Jejum / Proteína HMGB1 / Sirtuína 1 / Fígado Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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