Your browser doesn't support javascript.
loading
Multifunctional yolk-in-shell nanoparticles for pH-triggered drug release and imaging.
Chen, Hongyu; Qi, Bin; Moore, Thomas; Wang, Fenglin; Colvin, Daniel C; Sanjeewa, Liurukara D; Gore, John C; Hwu, Shiou-Jyh; Mefford, O Thompson; Alexis, Frank; Anker, Jeffrey N.
Afiliação
  • Chen H; Department of Chemistry, Center for optical materials science and engineering (COMSET) and environmental toxicology program, Clemson University, Clemson, SC, 29634, USA.
Small ; 10(16): 3364-70, 2014 Aug 27.
Article em En | MEDLINE | ID: mdl-24753264
Multifunctional nanoparticles are synthesized for both pH-triggered drug release and imaging with radioluminescence, upconversion luminescent, and magnetic resonance imaging (MRI). The particles have a yolk-in-shell morphology, with a radioluminescent core, an upconverting shell, and a hollow region between the core and shell for loading drugs. They are synthesized by controlled encapsulation of a radioluminescent nanophosphor yolk in a silica shell, partial etching of the yolk in acid, and encapsulation of the silica with an upconverting luminescent shell. Metroxantrone, a chemotherapy drug, was loaded into the hollow space between X-ray phosphor yolk and up-conversion phosphor shell through pores in the shell. To encapsulate the drug and control the release rate, the nanoparticles are coated with pH-responsive biocompatible polyelectrolyte layers of charged hyaluronic acid sodium salt and chitosan. The nanophosphors display bright luminescence under X-ray, blue light (480 nm), and near infrared light (980 nm). They also served as T1 and T2 MRI contrast agents with relaxivities of 3.5 mM(-1) s(-1) (r1 ) and 64 mM(-1) s(-1) (r2 ). These multifunctional nanocapsules have applications in controlled drug delivery and multimodal imaging.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Liberação Controlada de Fármacos / Concentração de Íons de Hidrogênio Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Liberação Controlada de Fármacos / Concentração de Íons de Hidrogênio Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article