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Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study.
Li, Zezhi; Zhang, Chen; Fan, Jinbo; Yuan, Chengmei; Huang, Jia; Chen, Jun; Yi, Zhenghui; Wang, Zuowei; Hong, Wu; Wang, Yong; Lu, Weihong; Guan, Yangtai; Wu, Zhiguo; Su, Yousong; Cao, Lan; Hu, Yingyan; Hao, Yong; Liu, Mingyuan; Yu, Shunying; Cui, Donghong; Xu, Lin; Song, Yanyan; Fang, Yiru.
Afiliação
  • Li Z; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Zhang C; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Fan J; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Yuan C; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Huang J; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Chen J; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Yi Z; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Wang Z; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Hong W; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Wang Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Lu W; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Guan Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Wu Z; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Su Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Cao L; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Hu Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Hao Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Liu M; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Yu S; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Cui D; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Xu L; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Song Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
  • Fang Y; Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders,
Br J Psychiatry ; 205(1): 29-35, 2014 Jul.
Article em En | MEDLINE | ID: mdl-24764546
ABSTRACT

BACKGROUND:

Early identification of patients with bipolar disorder during their first depressive episode is beneficial to the outcome of the disorder and treatment, but traditionally this has been a great challenge to clinicians. Recently, brain-derived neurotrophic factor (BDNF) has been suggested to be involved in the pathophysiology of bipolar disorder and major depressive disorder (MDD), but it is not clear whether BDNF levels can be used to predict bipolar disorder among patients in their first major depressive episode.

AIMS:

To explore whether BDNF levels can differentiate between MDD and bipolar disorder in the first depressive episode.

METHOD:

A total of 203 patients with a first major depressive episode as well as 167 healthy controls were recruited. After 3 years of bi-annual follow-up, 164 patients with a major depressive episode completed the study, and of these, 21 were identified as having bipolar disorder and 143 patients were diagnosed as having MDD. BDNF gene expression and plasma levels at baseline were compared among the bipolar disorder, MDD and healthy control groups. Logistic regression and decision tree methods were applied to determine the best model for predicting bipolar disorder at the first depressive episode.

RESULTS:

At baseline, patients in the bipolar disorder and MDD groups showed lower BDNF mRNA levels (P<0.001 and P = 0.02 respectively) and plasma levels (P = 0.002 and P = 0.01 respectively) compared with healthy controls. Similarly, BDNF levels in the bipolar disorder group were lower than those in the MDD group. These results showed that the best model for predicting bipolar disorder during a first depressive episode was a combination of BDNF mRNA levels with plasma BDNF levels (receiver operating characteristics (ROC) = 0.80, logistic regression; ROC = 0.84, decision tree).

CONCLUSIONS:

Our findings suggest that BDNF levels may serve as a potential differential diagnostic biomarker for bipolar disorder in a patient's first depressive episode.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Fator Neurotrófico Derivado do Encéfalo / Transtorno Depressivo Maior Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Fator Neurotrófico Derivado do Encéfalo / Transtorno Depressivo Maior Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article