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Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder.
Lu, Yun-Rong; Fu, Xin-Yan; Shi, Li-Gen; Jiang, Yan; Wu, Juan-Li; Weng, Xiao-Juan; Wang, Zhao-Pin; Wu, Xue-Yan; Lin, Zheng; Liu, Wei-Bo; Li, Hui-Chun; Luo, Jian-Hong; Bao, Ai-Min.
Afiliação
  • Bao AM; Department of Neurobiology; Key Laboratory of Medical Neurobiology of Ministry of Health of China; Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, P, R, China. baoaimin@zju.edu.cn.
BMC Psychiatry ; 14: 123, 2014 Apr 27.
Article em En | MEDLINE | ID: mdl-24767108
BACKGROUND: Amino acid neurotransmitters and nitric oxide (NO) are involved in the pathogenesis of major depressive disorder (MDD). Here we want to establish whether changes in their plasma levels may serve as biomarker for the melancholic subtype of this disorder. METHODS: Plasma levels of glutamic acid (Glu), aspartic acid (Asp), glycine (Gly), gamma-aminobutyric acid (GABA), and NO were determined in 27 medicine-naïve melancholic MDD patients and 30 matched controls. Seven of the MDD patients participated also in a follow-up study after 2 months' antidepressant treatment. The relationship between plasma and cerebral-spinal fluid (CSF) levels of these compounds was analyzed in an additional group of 10 non-depressed subjects. RESULTS: The plasma levels of Asp, Gly and GABA were significantly lower whereas the NO levels were significantly higher in melancholic MDD patients, also after 2 months of fluoxetine treatment. In the additional 10 non-depressed subjects, no significant correlation was observed between plasma and CSF levels of these compounds. CONCLUSION: These data give the first indication that decreased plasma levels of Asp, Gly and GABA and increased NO levels may serve as a clinical trait-marker for melancholic MDD. The specificity and selectivity of this putative trait-marker has to be investigated in follow-up studies.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Aminoácidos / Óxido Nítrico Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Aminoácidos / Óxido Nítrico Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article