A novel viscous dissecting gel for endoscopic submucosal dissection: a prospective survival study in a porcine model.
Endoscopy
; 46(7): 605-9, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24770967
ABSTRACT
BACKGROUND AND STUDY AIMS:
Endoscopic submucosal dissection (ESD) is a technically challenging procedure. A novel gel can facilitate ESD due to its submucosal dissecting properties. This prospective porcine survival study evaluated clinical and histologic parameters of hybrid ESD using the gel. PATIENTS ANDMETHODS:
Gastric submucosal lesions were created in six pigs and hybrid ESD was performed. Healing was assessed weekly until necropsy at Day 28.RESULTS:
En bloc resection was achieved in all lesions (mean size 40.7âmm). The mean total procedure time was 13.5 minutes and the mean resection time was 5.5 minutes. The mean total histologic injury score was 4. At necropsy, four ulcers had healed completely and two were <â6âmm in size.CONCLUSION:
Hybrid ESD of large gastric lesions in a porcine model can be facilitated by the novel gel, dramatically reducing procedure and resection times by eliminating the need for time-consuming submucosal dissection. The novel gel is safe and easy to use, and has the potential to simplify ESD. Further prospective human studies are needed to validate these findings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gastroscopia
/
Dissecação
/
Mucosa Gástrica
/
Géis
Tipo de estudo:
Evaluation_studies
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Observational_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article