Sedative and hypnotic effect of freeze-dried paeoniflorin and sini san freeze-dried powder in pentobarbital sodium-induced mice.
J Tradit Chin Med
; 34(2): 184-7, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24783931
ABSTRACT
OBJECTIVE:
To investigate the sedative and hypnotic activity of paeoniflorin and freeze-dried Sini San powder on mice and provide a reliable method for determining the pharmacodynamic material basis of Sini San.METHODS:
Male adult mice weighing 20-22 g were used in this study. Three experiments were carried out. Synergism with pentobarbital was used as an index for hypnotic effect. Loss of the righting reflex was used to determine the start of sleep. Sleep latency and sleeping time were recorded in each experiment.RESULTS:
The coefficient of variation of the suprathreshold dose (55 mg/kg) was significantly lower than that of the threshold dose. The sleep latency of mice was significantly decreased, and the sleeping time of mice was significantly prolonged. The effects of paeoniflorin and Sini San on prolonging the sleeping time of mice induced by pentobarbital sodium were significantly stronger than those in the control group.CONCLUSION:
Paeoniflorin produces significant sedative and hypnotic effects, and there is an obvious dose-effect relationship.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Pentobarbital
/
Benzoatos
/
Hidrocarbonetos Aromáticos com Pontes
/
Medicamentos de Ervas Chinesas
/
Glucosídeos
/
Hipnóticos e Sedativos
/
Distúrbios do Início e da Manutenção do Sono
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article