The relationship between dioxin congeners in the breast milk of Vietnamese women and sister chromatid exchange.
Int J Mol Sci
; 15(5): 7485-99, 2014 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-24786289
ABSTRACT
The aim of this study was to clarify the relationship between dioxin concentrations in breast milk and the sister chromatid exchange (SCE) frequency in women from herbicide-sprayed and non sprayed areas. Blood samples were taken from 21 women with high TCDD (tetrachlorodibenzo-p-dioxin) levels from sprayed areas, 23 women with moderate TCDD levels from sprayed areas, and 19 women from non sprayed areas to determine their SCE frequency. The SCE frequencies for the high and moderate TCDD groups from the sprayed area and for the non sprayed area group were 2.40, 2.19, and 1.48 per cell, respectively. Multiple regression analysis showed that the standardized ß values for 1,2,3,6,7,8-hexaCDD (ß = 0.60), 1,2,3,4,6,7,8-heptaCDD (ß = 0.64), and octaCDD (ß = 0.65) were higher than those for TCDD (ß = 0.34) and 1,2,3,7,8-pentaCDD (ß = 0.42). The adjusted R² value for polyCDDs (R² = 0.38) was higher than that for polyCDD toxic equivalents (TEQ (toxic equivalents); R² = 0.23). This study therefore shows that levels of hexa-, hepta-, and octaCDD, which were previously regarded as being less toxic than TCDD, are closely related to SCE frequency and that the level of dioxin (pg/g lipid) is potentially more useful as an indicator than TEQ value for explaining SCE frequency.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Troca de Cromátide Irmã
/
Dioxinas
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Poluentes Ambientais
/
Leite Humano
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Female
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Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article