The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice.

Holguin, Nilsson; Aguilar, Rhiannon; Harland, Robin A; Bomar, Bradley A; Silva, Matthew J

Holguin, Nilsson; Aguilar, Rhiannon; Harland, Robin A; Bomar, Bradley A; Silva, Matthew J.

Afiliação

Holguin N; Department of Orthopedics, Washington University, St. Louis, Missouri; and holguinn@wustl.edu.
Aguilar R; Department of Orthopedics, Washington University, St. Louis, Missouri; and.
Harland RA; Department of Biomedical Engineering, Washington University, St. Louis, Missouri.
Bomar BA; Department of Orthopedics, Washington University, St. Louis, Missouri; and.
Silva MJ; Department of Orthopedics, Washington University, St. Louis, Missouri; and Department of Biomedical Engineering, Washington University, St. Louis, Missouri.

J Appl Physiol (1985) ; 116(12): 1551-60, 2014 Jun 15.

Article em En | MEDLINE | ID: mdl-24790018

Assuntos

Envelhecimento/metabolismo; Envelhecimento/patologia; Disco Intervertebral/fisiopatologia; Vértebras Lombares/fisiopatologia; Via de Sinalização Wnt/fisiologia; Animais; Colágeno/metabolismo; Feminino; Glicosaminoglicanos/metabolismo; Humanos; Disco Intervertebral/metabolismo; Vértebras Lombares/metabolismo; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

WNT/ß-catenin; aging; caudal; mouse; tail

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Via de Sinalização Wnt / Disco Intervertebral / Vértebras Lombares Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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