Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages.
Biometals
; 27(5): 807-13, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24793588
ABSTRACT
Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Lipopolissacarídeos
/
Proteínas de Transporte de Cátions
/
Lactoferrina
/
Macrófagos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article