[An evaluation of the radioprotective effect of vitamin E on the salivary glands of radioactive iodine in rats]. / Radyoaktif iyot verilen siçanlarda tükürük bezleri üzerinde E vitaminin radyasyondan koruyucu etkisinin degerlendirilmesi.
Kulak Burun Bogaz Ihtis Derg
; 24(1): 21-9, 2014.
Article
em Tr
| MEDLINE
| ID: mdl-24798436
ABSTRACT
OBJECTIVES:
This study aims to examine the acute effect of vitamin E on salivary gland of radioactive iodine (RAI; 131I)-induced rats and to evaluate whether vitamin E have a radioprotective effect. MATERIALS ANDMETHODS:
Sixteen Wistar albino rats were used in the study. The rats were divided into two groups. The first group was administered (131)I orally and 1 ml physiological saline. The second group was administered (131)I and 1 ml vitamin E intraperitoneally. Vitamin E was started two days before the RAI therapy and continued for seven days. On the eighth day, salivary glands were removed and evaluated histopathologically.RESULTS:
There was no statistically significant difference between the groups. The changes in the interstitial space of all glands and in acinar epithelial cells of parotid and sublingual glands were observed in a lower number of the rats of vitamin E group, compared to the controls. Except panacinar inflammation, histopathological changes in acinar epithelial cells of the submandibular gland were noticed in a lower number of the rats of vitamin E group.CONCLUSION:
Considering the changes in the interstitial space and acinar epithelial cells in a lower number of the rats of vitamin E group, we conclude that vitamin E may have protective effects for interstitial space of all glands and acinar epithelial cells of the parotid and sublingual glands during the acute period.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Protetores contra Radiação
/
Glândulas Salivares
/
Vitamina E
/
Radioisótopos do Iodo
Limite:
Animals
Idioma:
Tr
Ano de publicação:
2014
Tipo de documento:
Article