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Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.
Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Pereira de Almeida, Luís.
Afiliação
  • Simões AT; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal Faculty of Pharmacy, University of Coimbra, Coimbra 3000-548, Portugal.
  • Gonçalves N; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal Faculty of Pharmacy, University of Coimbra, Coimbra 3000-548, Portugal.
  • Nobre RJ; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal.
  • Duarte CB; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal Faculty of Sciences and Technology, Department of Life Sciences, University of Coimbra, Coimbra 3001-401, Portugal.
  • Pereira de Almeida L; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal Faculty of Pharmacy, University of Coimbra, Coimbra 3000-548, Portugal luispa@cnc.uc.pt luispa@ci.uc.pt.
Hum Mol Genet ; 23(18): 4932-44, 2014 Sep 15.
Article em En | MEDLINE | ID: mdl-24817574
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Calpaína / Doença de Machado-Joseph Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Calpaína / Doença de Machado-Joseph Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article