12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.

Liu, Min; Saeki, Kazuko; Matsunobu, Takehiko; Okuno, Toshiaki; Koga, Tomoaki; Sugimoto, Yukihiko; Yokoyama, Chieko; Nakamizo, Satoshi; Kabashima, Kenji; Narumiya, Shuh; Shimizu, Takao; Yokomizo, Takehiko

Liu, Min; Saeki, Kazuko; Matsunobu, Takehiko; Okuno, Toshiaki; Koga, Tomoaki; Sugimoto, Yukihiko; Yokoyama, Chieko; Nakamizo, Satoshi; Kabashima, Kenji; Narumiya, Shuh; Shimizu, Takao; Yokomizo, Takehiko.

Afiliação

Liu M; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan Department of Medical Biochemistry, Kyushu University, Fukuoka 812-8582, Japan.
Saeki K; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan Department of Medical Biochemistry, Kyushu University, Fukuoka 812-8582, Japan ksaeki@juntendo.ac.jp yokomizo-tky@umin.ac.jp.
Matsunobu T; Department of Medical Biochemistry, Kyushu University, Fukuoka 812-8582, Japan.
Okuno T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan Department of Medical Biochemistry, Kyushu University, Fukuoka 812-8582, Japan.
Koga T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan Department of Medical Biochemistry, Kyushu University, Fukuoka 812-8582, Japan.
Sugimoto Y; Department of Pharmaceutical Biochemistry, Kumamoto University, Kumamoto 862-0973, Japan.
Yokoyama C; Department of Metabolism and Atherosclerosis, Osaka University, Osaka 565-0871, Japan.
Nakamizo S; Department of Dermatology and Department of Pharmacology, Kyoto University, Kyoto 606-8501, Japan.
Kabashima K; Department of Dermatology and Department of Pharmacology, Kyoto University, Kyoto 606-8501, Japan.
Narumiya S; Department of Dermatology and Department of Pharmacology, Kyoto University, Kyoto 606-8501, Japan.
Shimizu T; Department of Lipid Signaling, National Center for Global Health and Medicine, Tokyo 162-0052, Japan.
Yokomizo T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan Department of Medical Biochemistry, Kyushu University, Fukuoka 812-8582, Japan ksaeki@juntendo.ac.jp yokomizo-tky@umin.ac.jp.

J Exp Med ; 211(6): 1063-78, 2014 Jun 02.

Article em En | MEDLINE | ID: mdl-24821912

Assuntos

Movimento Celular; Epiderme/metabolismo; Ácidos Graxos Insaturados/metabolismo; Queratinócitos/metabolismo; Receptores do Leucotrieno B4/metabolismo; Cicatrização/fisiologia; Animais; Linhagem Celular; Células Cultivadas; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/fisiopatologia; Ensaio de Imunoadsorção Enzimática; Epiderme/fisiopatologia; Citometria de Fluxo; Perfilação da Expressão Gênica; Humanos; Interleucina-1beta/genética; Queratinócitos/citologia; Masculino; Malondialdeído/metabolismo; Metaloproteinase 9 da Matriz/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Análise de Sequência com Séries de Oligonucleotídeos; Receptores do Leucotrieno B4/agonistas; Receptores do Leucotrieno B4/genética; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Fator de Necrose Tumoral alfa/genética; Cicatrização/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Queratinócitos / Movimento Celular / Receptores do Leucotrieno B4 / Epiderme / Ácidos Graxos Insaturados Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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