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HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
Serrano-Villar, Sergio; Sainz, Talia; Lee, Sulggi A; Hunt, Peter W; Sinclair, Elizabeth; Shacklett, Barbara L; Ferre, April L; Hayes, Timothy L; Somsouk, Ma; Hsue, Priscilla Y; Van Natta, Mark L; Meinert, Curtis L; Lederman, Michael M; Hatano, Hiroyu; Jain, Vivek; Huang, Yong; Hecht, Frederick M; Martin, Jeffrey N; McCune, Joseph M; Moreno, Santiago; Deeks, Steven G.
Afiliação
  • Serrano-Villar S; Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain.
  • Sainz T; Molecular Immune Biology Laboratory, University Hospital Gregorio Marañón, Madrid, Spain.
  • Lee SA; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Hunt PW; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Sinclair E; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Shacklett BL; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America.
  • Ferre AL; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America.
  • Hayes TL; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America.
  • Somsouk M; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Hsue PY; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Van Natta ML; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America.
  • Meinert CL; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America.
  • Lederman MM; Case Western Reserve University, Cleveland, Ohio, United States of America.
  • Hatano H; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Jain V; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Huang Y; Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America.
  • Hecht FM; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Martin JN; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.
  • McCune JM; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
  • Moreno S; Department of Infectious Diseases, University Hospital Ramón y Cajal, Madrid, Spain.
  • Deeks SG; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
PLoS Pathog ; 10(5): e1004078, 2014 May.
Article em En | MEDLINE | ID: mdl-24831517
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Infecções por HIV / Subpopulações de Linfócitos T / Relação CD4-CD8 / Linfócitos T CD8-Positivos / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Infecções por HIV / Subpopulações de Linfócitos T / Relação CD4-CD8 / Linfócitos T CD8-Positivos / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article