The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction.
Nano Lett
; 14(7): 3945-52, 2014 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-24848978
ABSTRACT
We show that the nanoscale adhesion geometry controls the spreading and differentiation of epidermal stem cells. We find that cells respond to such hard nanopatterns similarly to their behavior on soft hydrogels. Cellular responses were seen to stem from local changes in diffusion dynamics of the adapter protein vinculin and associated impaired mechanotransduction rather than impaired recruitment of proteins involved in focal adhesion formation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Vinculina
/
Adesões Focais
/
Mecanotransdução Celular
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Nanoestruturas
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article