Synthesis, preliminary bioevaluation and computational analysis of caffeic acid analogues.
Int J Mol Sci
; 15(5): 8808-20, 2014 May 16.
Article
em En
| MEDLINE
| ID: mdl-24857914
ABSTRACT
A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Cafeicos
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article