Thiolated human serum albumin cross-linked dextran hydrogels as a macroscale delivery system.
Soft Matter
; 10(27): 4869-74, 2014 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-24866323
ABSTRACT
Hydrogels play an important role in macroscale delivery systems by enabling the transport of cells and molecules. Here we present a facile and benign method to prepare a dextran-based hydrogel (Dex-sHSA) using human serum albumin (HSA) as a simultaneous drug carrier and covalent cross-linker. Drug binding affinity of the albumin protein was conserved in the thiolation step using 2-iminothiolane and subsequently, in the in situ gelation step. Oscillation rheometry studies confirmed the formation of a three-dimensional viscoelastic network upon reaction of dextran and the HSA protein. The mechanical properties of Dex-sHSA hydrogel can be tuned by the protein concentration, and the degree of thiolation of sHSA. Sustained release of hydrophobic drugs, such as ibuprofen, paclitaxel and dexamethasone, from the Dex-sHSA network was shown over one week. Hence, this albumin-based dextran hydrogel system demonstrates its potential as a macroscale delivery system of hydrophobic therapeutics for a wide range of biomedical applications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Albumina Sérica
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Portadores de Fármacos
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Dextranos
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Hidrogéis
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article