Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells.
Chem Commun (Camb)
; 50(55): 7254-7, 2014 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-24870379
ABSTRACT
Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Endocitose
/
Dendrímeros
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article