Cytotoxic markers associate with protection against malaria in human volunteers immunized with Plasmodium falciparum sporozoites.

Bijker, Else M; Teirlinck, Anne C; Schats, Remko; van Gemert, Geert-Jan; van de Vegte-Bolmer, Marga; van Lieshout, Lisette; IntHout, Joanna; Hermsen, Cornelus C; Scholzen, Anja; Visser, Leo G; Sauerwein, Robert W

Bijker, Else M; Teirlinck, Anne C; Schats, Remko; van Gemert, Geert-Jan; van de Vegte-Bolmer, Marga; van Lieshout, Lisette; IntHout, Joanna; Hermsen, Cornelus C; Scholzen, Anja; Visser, Leo G; Sauerwein, Robert W.

Afiliação

Bijker EM; Department of Medical Microbiology.
Teirlinck AC; Department of Medical Microbiology.
Schats R; Department of Infectious Diseases.
van Gemert GJ; Department of Medical Microbiology.
van de Vegte-Bolmer M; Department of Medical Microbiology.
van Lieshout L; Department of Medical Microbiology, Department of Parasitology, Leiden University Medical Center, The Netherlands.
IntHout J; Department for Health Evidence, Section Biostatistics, Radboud university medical center, Nijmegen.
Hermsen CC; Department of Medical Microbiology.
Scholzen A; Department of Medical Microbiology.
Visser LG; Department of Infectious Diseases.
Sauerwein RW; Department of Medical Microbiology.

J Infect Dis ; 210(10): 1605-15, 2014 Nov 15.

Article em En | MEDLINE | ID: mdl-24872326

Assuntos

Biomarcadores; Vacinas Antimaláricas/imunologia; Malária Falciparum/imunologia; Malária Falciparum/prevenção & controle; Plasmodium falciparum/imunologia; Esporozoítos/imunologia; Linfócitos T Citotóxicos/imunologia; Adolescente; Adulto; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD8-Positivos/imunologia; Feminino; Citometria de Fluxo; Voluntários Saudáveis; Humanos; Leucócitos Mononucleares/imunologia; Vacinas Antimaláricas/administração & dosagem; Masculino; Resultado do Tratamento; Adulto Jovem

Palavras-chave

Plasmodium; T cells; chloroquine; cytotoxicity; degranulation; granzyme B; immunity; immunization; malaria; protection

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Linfócitos T Citotóxicos / Biomarcadores / Malária Falciparum / Vacinas Antimaláricas / Esporozoítos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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