Trifluoroethanethiol: an additive for efficient one-pot peptide ligation-desulfurization chemistry.
J Am Chem Soc
; 136(23): 8161-4, 2014 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-24873761
ABSTRACT
Native chemical ligation followed by desulfurization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding, one-pot ligation-desulfurization protocol that uses trifluoroethanethiol (TFET) as a novel thiol additive. The synthetic utility of this TFET-enabled methodology is demonstrated by the efficient multi-step one-pot syntheses of two tick-derived proteins, chimadanin and madanin-1, without the need for any intermediary purification.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trifluoretanol
/
Proteínas de Insetos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article