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Serum lipid profile in oral precancer and cancer: a diagnostic or prognostic marker?
Garg, Deepanshu; Sunil, M K; Singh, Param Pal; Singla, Neetu; Rani, S R Ashwini; Kaur, Beant.
Afiliação
  • Garg D; Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
  • Sunil MK; Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
  • Singh PP; Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
  • Singla N; Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
  • Rani SR; Department of Oral Medicine & Radiology, School of Dental Sciences, KIMSDU, Maharashtra, India.
  • Kaur B; Department of Oral Medicine & Radiology, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
J Int Oral Health ; 6(2): 33-9, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24876700
BACKGROUND: Changes in lipid profile have been associated with malignancy because of their key role in the maintenance the integrity of the cell membrane. This study evaluated the alterations in serum lipid profile in untreated patients of oral submucus fibrosis (OSMF), oral leukoplakia, and oral lichen planus and proven cases of oral cancer with respect to healthy controls. MATERIALS & METHODS: In this case control study, 20 clinically and histopathologically proven patients of oral precancer and oral cancer each were compared with 20 healthy controls. In these groups, serumlipids including: (i) Total cholesterol. (ii) Triglycerides (TGL). (iii) High density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and very low density lipoprotein cholesterol (VLDL) were analyzed. RESULTS: Decrease in plasma total cholesterol, triglycerides, HDL, LDL, VLDL in the subjects with the oral precancer and oral cancer as compared to the controls was statistically significant. There was also decrease in plasma levels of TGL and VLDL in oral cancer subjects as compared to precancer subjects. Thus, it was found that there is an inverse relationship between plasma lipid levels and patients. CONCLUSION: Post operative morbidity was increasing along with more operating time and increase in the depth of mandibular third molar impaction. How to cite the article: Garg D, Sunil MK, Singh PP, Singla N, Rani SR, Kaur B. Serum lipid profile in oral precancer and cancer: a diagnostic or prognostic marker? J Int Oral Health 2014;6(2):33-9.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article