Characteristics and determinants of endurance cycle ergometry and six-minute walk distance in patients with COPD.
BMC Pulm Med
; 14: 97, 2014 May 31.
Article
em En
| MEDLINE
| ID: mdl-24885117
ABSTRACT
BACKGROUND:
Exercise tolerance can be assessed by the cycle endurance test (CET) and six-minute walk test (6MWT) in patients with Chronic Obstructive Pulmonary Disease (COPD). We sought to investigate the characteristics of functional exercise performance and determinants of the CET and 6MWT in a large clinical cohort of COPD patients.METHODS:
A dataset of 2053 COPD patients (43% female, age 66.9 ± 9.5 years, FEV1% predicted 48.2 ± 23.2) was analyzed retrospectively. Patients underwent, amongst others, respiratory function evaluation; medical tests and questionnaires, one maximal incremental cycle test where peak work rate was determined and two functional exercise tests a CET at 75% of peak work rate and 6MWT. A stepwise multiple linear regression was used to assess determinants.RESULTS:
On average, patients had impaired exercise tolerance (peak work rate 56 ± 27% predicted, 6MWT 69 ± 17% predicted). A total of 2002 patients had CET time of duration (CET-Tend) less than 20 min while only 51 (2.5%) of the patients achieved 20 min of CET-Tend . In former patients, the percent of predicted peak work rate achieved differed significantly between men (48 ± 21% predicted) and women (67 ± 31% predicted). In contrast, CET-Tend was longer in men (286 ± 174 s vs 250 ± 153 s, p < 0.001). Also, six minute walking distance (6MWD) was higher in men compared to women, both in absolute terms as in percent of predicted (443 m, 67%predicted vs 431 m, 72%predicted, p < 0.05). Gender was associated with the CET-Tend but BMI, FEV1 and FRC were related to the 6MWD highlighting the different determinants of exercise performance between CET and 6MWT.CONCLUSIONS:
CET-Tend is a valuable outcome of CET as it is related to multiple clinical aspects of disease severity in COPD. Gender difference should temper the interpretation of CET.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
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Resistência Física
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Caminhada
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Ergometria
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Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article