Synthesis and cytotoxicity of 2,3-enopyranosyl C-linked conjugates of genistein.
Molecules
; 19(6): 7072-93, 2014 May 30.
Article
em En
| MEDLINE
| ID: mdl-24886936
ABSTRACT
A series of glycoconjugates, derivatives of genistein containing a C-glycosylated carbohydrate moiety, were synthesized and their anticancer activity was tested in vitro in the human cell lines HCT 116 and DU 145. The target compounds 15-17 were synthesized by treating ω-bromoalkyl C-glycosides derived from L-rhamnal (1) with a tetrabutylammonium salt of genistein. The new, metabolically stable analogs of previously studied O-glycosidic genistein derivatives inhibited proliferation of cancer cell lines through inhibition of the cell cycle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genisteína
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article