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Numerosol A-D, new cembranoid diterpenes from the soft coral Sinularia numerosa.
Tseng, Yen-Ju; Yang, Yuan-Chien; Wang, Shang-Kwei; Duh, Chang-Yih.
Afiliação
  • Tseng YJ; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pit0424@yahoo.com.tw.
  • Yang YC; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. m995020028@student.nsysu.edu.tw.
  • Wang SK; Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. skwang@cc.kmu.edu.tw.
  • Duh CY; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. yihduh@mail.nsysu.edu.tw.
Mar Drugs ; 12(6): 3371-80, 2014 Jun 03.
Article em En | MEDLINE | ID: mdl-24897385
Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia P388 / Antozoários / Diterpenos / Antineoplásicos Limite: Animals / Humans País como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia P388 / Antozoários / Diterpenos / Antineoplásicos Limite: Animals / Humans País como assunto: Asia Idioma: En Ano de publicação: 2014 Tipo de documento: Article