Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation.

Qin, Xiangjing; Hao, Zhitai; Tian, Qingnan; Zhang, Zhemin; Zhou, Chun; Xie, Wei

Qin, Xiangjing; Hao, Zhitai; Tian, Qingnan; Zhang, Zhemin; Zhou, Chun; Xie, Wei.

Afiliação

Qin X; From the Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University, Guangzhou 510275, China, Center for Cellular and Structural Biology, The Sun Yat-Sen University, 132 E. Circle, University City, Guangzh
Hao Z; From the Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University, Guangzhou 510275, China, Center for Cellular and Structural Biology, The Sun Yat-Sen University, 132 E. Circle, University City, Guangzh
Tian Q; From the Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University, Guangzhou 510275, China, Center for Cellular and Structural Biology, The Sun Yat-Sen University, 132 E. Circle, University City, Guangzh
Zhang Z; From the Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University, Guangzhou 510275, China, Center for Cellular and Structural Biology, The Sun Yat-Sen University, 132 E. Circle, University City, Guangzh
Zhou C; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065.
Xie W; From the Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Sciences, The Sun Yat-Sen University, Guangzhou 510275, China, Center for Cellular and Structural Biology, The Sun Yat-Sen University, 132 E. Circle, University City, Guangzh

J Biol Chem ; 289(29): 20359-69, 2014 Jul 18.

Article em En | MEDLINE | ID: mdl-24898252

Assuntos

Glicina-tRNA Ligase/química; RNA de Transferência de Glicina/química; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Domínio Catalítico/genética; Doença de Charcot-Marie-Tooth/enzimologia; Doença de Charcot-Marie-Tooth/genética; Cristalografia por Raios X; Glicina-tRNA Ligase/genética; Glicina-tRNA Ligase/metabolismo; Glicosilação; Células HeLa; Humanos; Substâncias Macromoleculares/química; Substâncias Macromoleculares/metabolismo; Modelos Moleculares; Mutagênese Insercional; Proteínas Mutantes/química; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Conformação de Ácido Nucleico; Conformação Proteica; RNA de Transferência de Glicina/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Thermus thermophilus/enzimologia; Thermus thermophilus/genética

Palavras-chave

Aminoacyl tRNA Synthetase; Cocrystal; Crystal Structure; Neurological Disease; Protein Conformation; RNA-Protein Interaction; Transfer RNA (tRNA)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA de Transferência de Glicina / Glicina-tRNA Ligase Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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