Evaluation of preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy: preliminary results.
Eur Rev Med Pharmacol Sci
; 18(10): 1549-53, 2014.
Article
em En
| MEDLINE
| ID: mdl-24899616
ABSTRACT
OBJECTIVES:
Upper air obstruction leads hypoxia, it is also known that S-100B levels increase by glial activations indicate cerebral hypoxic injury. This study aimed to evaluate the preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy. PATIENTS ANDMETHODS:
The study comprised 40 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 40 age-gender matched control patients. Blood samples were taken from the patients preoperatively and at four weeks postoperatively. Preoperative and postoperative serum S-100B levels were analyzed.RESULTS:
The serum S-100B levels in the preoperative period were found to be significantly higher compared to those of the control group (p < 0.05). The S-100B levels were significantly decreased in the postoperative period (p < 0.05).CONCLUSIONS:
The development of chronic adenotonsillar hypertrophy would play a role in increased S-100B levels. This indicates that neuronal damage would exists in patients with chronic adenotonsillar hypertrophy.
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Base de dados:
MEDLINE
Assunto principal:
Tonsila Palatina
/
Tonsila Faríngea
/
Subunidade beta da Proteína Ligante de Cálcio S100
/
Hipertrofia
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article