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Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.
Nishi, Takahide; Miyazaki, Shojiro; Takemoto, Toshiyasu; Suzuki, Keisuke; Iio, Yukiko; Nakajima, Katsuyoshi; Ohnuki, Takashi; Kawase, Yumi; Nara, Futoshi; Inaba, Shinichi; Izumi, Takashi; Yuita, Hiroshi; Oshima, Keiko; Doi, Hiromi; Inoue, Ryotaku; Tomisato, Wataru; Kagari, Takashi; Shimozato, Takaichi.
Afiliação
  • Nishi T; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Miyazaki S; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Takemoto T; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Suzuki K; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Iio Y; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Nakajima K; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Ohnuki T; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Kawase Y; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Nara F; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Inaba S; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Izumi T; Lead Discovery & Optimization Research Laboratories I, Cardiovascular-Metabolics Research Laboratories, and Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Yuita H; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
  • Oshima K; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
  • Doi H; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
  • Inoue R; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
  • Tomisato W; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
  • Kagari T; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
  • Shimozato T; Oncology Research Laboratories and Frontier Research Laboratories, Daiichi Sankyo Co., Ltd. , 1-16-13 Kitakasai, Edogawa-ku, Tokyo, 134-8630, Japan.
ACS Med Chem Lett ; 2(5): 368-72, 2011 May 12.
Article em En | MEDLINE | ID: mdl-24900318
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2011 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2011 Tipo de documento: Article