Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.
ACS Med Chem Lett
; 2(6): 424-7, 2011 Jun 09.
Article
em En
| MEDLINE
| ID: mdl-24900324
ABSTRACT
Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. Inhibition of cholesteryl ester transfer protein (CETP) has been shown to elevate HDL-C levels in human subjects. This letter describes the discovery of a novel and potent (<100 nM IC50 for the inhibition of CE transfer) CETP inhibitor scaffold containing an oxazolidinone core.
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MEDLINE
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En
Ano de publicação:
2011
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Article