Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin.
J Microencapsul
; 31(7): 694-9, 2014.
Article
em En
| MEDLINE
| ID: mdl-24903450
ABSTRACT
CONTEXT Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered. OBJECTIVES:
To prepare chitosan/xanthan gum microparticles to increase QUE oral bioavailability and optimize its release in the colon. MATERIALS ANDMETHODS:
Chitosan/xanthan gum hydrogel embedding QUE was spray-dried to obtain microparticles characterized by size, scanning electron microscopy, differential scanning calorimetry and X-ray diffraction. Microparticles were compressed into tablets, coated with Eudragit® to further prevent degradation in acidic pH. The swelling degree and QUE release in simulated gastric and intestinal pH were investigated.RESULTS:
Microparticles were smooth and spherical, around 5 µm, with successful QUE loading. Microparticle tablets provided resistance to acidic conditions, allowing complete drug release in alkaline pH, mimicking colonic environment. The release was controlled by non-Fickian diffusion of the dissolved drug out of the swollen polymeric tablet. DISCUSSION ANDCONCLUSION:
Microparticle tablets represent a promising dosage form for QUE delivery to the colon in the oral therapy of inflammatory-based disorders.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
/
Quercetina
/
Colo
/
Quitosana
/
Antioxidantes
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article