Palladium-nanoparticle-catalyzed 1,7-palladium migration involving C-H activation, followed by intramolecular amination: regioselective synthesis of N1-arylbenzotriazoles and an evaluation of their inhibitory activity toward indoleamine 2,3-dioxygenase.
J Org Chem
; 79(13): 6366-71, 2014 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-24906179
ABSTRACT
A sulfur-modified gold-supported palladium material (SAPd) has been developed bearing palladium nanoparticles on its surface. Herein, we report for the first time the use of SAPd to affect a Pd-nanoparticle-catalyzed 1,7-Pd migration reaction for the synthesis of benzotriazoles via C-H bond activation. The resulting benzotriazoles were evaluated in terms of their inhibitory activity toward indoleamine 2,3-dioxygenase.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Triazóis
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Inibidores Enzimáticos
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Indolamina-Pirrol 2,3,-Dioxigenase
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Nanopartículas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article