Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing.
AIDS Res Hum Retroviruses
; 30(8): 806-11, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24914638
ABSTRACT
Acute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with dramatic subpopulation shifts in a single acutely infected participant providing further insight into the genetic dynamics of acute HIV-1 infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
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Infecções por HIV
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HIV-1
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Produtos do Gene gag do Vírus da Imunodeficiência Humana
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Sequenciamento de Nucleotídeos em Larga Escala
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article