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Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.
Chagas, Andrezza C; McPhie, Peter; San, Hong; Narum, David; Reiter, Karine; Tokomasu, Fuyuki; Brayner, Fabio A; Alves, Luiz C; Ribeiro, José M C; Calvo, Eric.
Afiliação
  • Chagas AC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
  • McPhie P; Physical and Biochemistry Section, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.
  • San H; Animal Surgery and Resources Core, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America.
  • Narum D; Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH, Bethesda, Maryland, United States of America.
  • Reiter K; Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH, Bethesda, Maryland, United States of America.
  • Tokomasu F; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
  • Brayner FA; Centro de Pesquisas Aggeu Magalhães (CPqAM/FIOCRUZ) and Laboratório de Imunopatologia Keizo Asami. Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
  • Alves LC; Centro de Pesquisas Aggeu Magalhães (CPqAM/FIOCRUZ) and Laboratório de Imunopatologia Keizo Asami. Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
  • Ribeiro JM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
  • Calvo E; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, United States of America.
PLoS Negl Trop Dis ; 8(6): e2947, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24921659
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glândulas Salivares / Simuliidae / Inibidores da Agregação Plaquetária / Glicoproteínas da Membrana de Plaquetas / Proteínas de Insetos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glândulas Salivares / Simuliidae / Inibidores da Agregação Plaquetária / Glicoproteínas da Membrana de Plaquetas / Proteínas de Insetos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article