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Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy.
Schrand, Brett; Berezhnoy, Alexey; Brenneman, Randall; Williams, Anthony; Levay, Agata; Kong, Ling-Yuan; Rao, Ganesh; Zhou, Shouhao; Heimberger, Amy B; Gilboa, Eli.
Afiliação
  • Schrand B; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Berezhnoy A; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Brenneman R; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Williams A; Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida.
  • Levay A; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Kong LY; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Rao G; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Zhou S; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Heimberger AB; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Gilboa E; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida. egilboa@med.miami.edu.
Cancer Immunol Res ; 2(9): 867-77, 2014 Sep.
Article em En | MEDLINE | ID: mdl-24938283
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T CD8-Positivos / Aptâmeros de Nucleotídeos / Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / Terapia de Alvo Molecular / Imunoterapia / Neoplasias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T CD8-Positivos / Aptâmeros de Nucleotídeos / Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / Terapia de Alvo Molecular / Imunoterapia / Neoplasias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article