Effects of integrins and integrin αvß3 inhibitor on angiogenesis in cerebral ischemic stroke.

ABSTRACT

Integrins such as αvß3, α5ß1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvß3 after cerebral ischemic stroke can promote angiogenesis, which in turn improves functional recovery. In addition, the integrin αvß3 inhibitor can block the blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) and also can reduce inflammatory reaction, decrease the deposition of fibrinogen. Other studies showed that integrin αvß3 is not essential in revascularization. Therefore, the effect of integrin αvß3 in the whole process of brain function recovery merits further study.