Association of p73 G4C14-to-A4T14 polymorphism with lung cancer risk.
Tumour Biol
; 35(9): 9311-6, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24943681
ABSTRACT
Conflicting results were implicated in both single case-control studies and meta-analyses of the correlation between p73 G4C14-to-A4T14 polymorphism and lung cancer risk. We designed this study to further assess the association by meta-analysis. A meta-analysis was performed based on five case-control studies (5,467 subjects) retrieved from PubMed and Embase. Odds ratios (ORs) with 95 % confidence intervals (CIs) were measured for the association using the models of random effects and fixed effects. The results showed no evidence between p73 G4C14-to-A4T14 polymorphism and lung cancer risk in any genetic model (allele model OR, 1.06, 95 % CI, 0.89-1.26; homozygote genotypes OR, 1.18, 95 % CI, 0.80-1.73; heterozygote genotypes OR, 1.04, 95 % CI, 0.89-1.23; dominant model OR, 1.05, 95 % CI, 0.89-1.24; recessive model OR, 1.17, 95 % CI, 0.93-1.47). Subgroup analyses according to ethnicity, however, detected significant association in Caucasian population. Our study provides evidence that p73 G4C14-to-A4T14 polymorphism may play a major role in susceptibility to lung cancer in Caucasians.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Proteínas Nucleares
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Predisposição Genética para Doença
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Proteínas Supressoras de Tumor
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Proteínas de Ligação a DNA
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article