Intracellular calcium levels can regulate Importin-dependent nuclear import.
Biochem Biophys Res Commun
; 450(1): 812-7, 2014 Jul 18.
Article
em En
| MEDLINE
| ID: mdl-24953690
ABSTRACT
We previously showed that increased intracellular calcium can modulate Importin (Imp)ß1-dependent nuclear import of SRY-related chromatin remodeling proteins. Here we extend this work to show for the first time that high intracellular calcium inhibits Impα/ß1- or Impß1-dependent nuclear protein import generally. The basis of this relates to the mislocalisation of the transport factors Impß1 and Ran, which show significantly higher nuclear localization in contrast to various other factors, and RCC1, which shows altered subnuclear localisation. The results here establish for the first time that intracellular calcium modulates conventional nuclear import through direct effects on the nuclear transport machinery.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
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Cálcio
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Proteínas de Ciclo Celular
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Proteína ran de Ligação ao GTP
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Fatores de Troca do Nucleotídeo Guanina
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Transporte Ativo do Núcleo Celular
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Beta Carioferinas
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Líquido Intracelular
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article