Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis.

Agalave, Nilesh M; Larsson, Max; Abdelmoaty, Sally; Su, Jie; Baharpoor, Azar; Lundbäck, Peter; Palmblad, Karin; Andersson, Ulf; Harris, Helena; Svensson, Camilla I

Agalave, Nilesh M; Larsson, Max; Abdelmoaty, Sally; Su, Jie; Baharpoor, Azar; Lundbäck, Peter; Palmblad, Karin; Andersson, Ulf; Harris, Helena; Svensson, Camilla I.

Afiliação

Agalave NM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Pain ; 155(9): 1802-1813, 2014 Sep.

Article em En | MEDLINE | ID: mdl-24954167

Assuntos

Artrite Experimental/metabolismo; Proteína HMGB1/metabolismo; Hiperalgesia/metabolismo; Neuroglia/metabolismo; Medula Espinal/metabolismo; Receptor 4 Toll-Like/metabolismo; Animais; Artrite Experimental/fisiopatologia; Comportamento Animal/fisiologia; Feminino; Hiperalgesia/fisiopatologia; Masculino; Camundongos; Medula Espinal/fisiopatologia

Palavras-chave

Cytokine; HMGB1; Hypersensitivity; Inflammation; Pain; Rheumatoid arthritis; Spinal cord; TLR4

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Medula Espinal / Neuroglia / Proteína HMGB1 / Receptor 4 Toll-Like / Hiperalgesia Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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