Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: a controversial issue.
World J Gastroenterol
; 20(23): 7325-38, 2014 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-24966603
ABSTRACT
Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients. The potential role of autophagy in disease is increasingly recognised and investigated in the last decade. Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism. Hence, dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease. However, controversy of the exact role of autophagy in the lipid metabolism exists some publications report a lipolytic function of autophagy, whereas others claim a lipogenic function. This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism, hepatic insulin resistance, steatohepatitis and hepatic fibrogenesis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Hepatopatia Gordurosa não Alcoólica
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Fígado
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article